About Calcilytix & BridgeBio Pharma
Calcilytix Therapeutics, an affiliate of BridgeBio Pharma, is focused on developing encaleret (CLTX-305), a negative allosteric modulator of the calcium-sensing receptor (CaSR) aimed at treating Autosomal Dominant Hypocalcemia Type 1 (ADH1), a genetic cause of hypoparathyroidism. Encaleret is currently undergoing a Phase 3 clinical study and has been granted Orphan Drug and Fast Track Designations by the US FDA.
BridgeBio Pharma is a biopharmaceutical company dedicated to discovering, creating, testing, and delivering transformative medicines for patients suffering from genetic diseases and cancers with clear genetic drivers. Since its inception in 2015, BridgeBio has developed a portfolio of over 30 drug development programs ranging from preclinical to late-stage development across various therapeutic areas, including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.
BridgeBio is committed to scientific excellence and rapid execution, translating today's scientific discoveries into tomorrow's medicines. The company has U.S. offices in San Francisco, Palo Alto, and Raleigh, with smaller satellite offices throughout the country. Internationally, BridgeBio has offices in Montreal, Canada, and Zurich, Switzerland, and is expanding across Europe.
For more information about our story and company culture, visit us at Calcilytix and BridgeBio.
Position Overview
The Senior Manager/Associate Director of Drug Substance Development and Manufacturing will oversee critical scientific, regulatory, and business functions related to process chemistry. Key responsibilities include overseeing late development and launch preparation activities, developing chemical processes for active pharmaceutical ingredients (APIs) and regulatory starting materials (RSMs), process scale-up, technology transfer, and validation of chemical processes. Effective management of Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) is crucial for achieving these goals. The role also involves contributing to the overall strategy and authoring the Module 3 drug substance sections of regulatory submissions.
Key Responsibilities
Qualifications and Skills
What We Offer
Salary Range
$155,000 - $205,000 USD (California-based candidates; ranges may vary for positions in other states).
Commitment to Diversity, Equity & Inclusion
BridgeBio is committed to providing a diverse, inclusive, and equitable work environment.
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Remote, USA | Remote - Europe | Switzerland | Remote |Makkah :
Jeddah | Khulais | Riyadh | Najran | Rabigh |Catalonia :
Barcelona |Republic of Thailand :
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