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    Senior Principal Scientist, Cancer Cell Programs (Post-Can Research)

    Pfizer
    5+ years
    Not Disclosed
    Remote, USA
    10 Nov. 13, 2024
    Job Description
    Job Type: Full Time Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

    Role Summary:

    Pfizer’s Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Principal Scientist (PhD) to join the Post-CAN Research group focused on translating basic discoveries in cancer cell biology into novel therapeutics. The ideal candidate will lead preclinical research with a motivated team of scientists to advance clinical and pre-clinical drug programs in oncology. The candidate will focus on translational research in oncology cell signaling and cell cycle assets, using state-of-the-art approaches to understand mechanisms of action and resistance. A strong scientific leadership track record, along with publications in scientific journals, is essential for this role.

    Role Responsibilities:

    • Develop innovative strategies for understanding the role of cell signaling and/or cell cycle targets in cancer progression, drug resistance, and immune modulation.
    • Lead preclinical research for oncology assets to advance mechanism-of-action studies, develop patient responder hypotheses, elucidate mechanisms of resistance, and identify rational drug combinations.
    • Provide scientific leadership as the biology lead for post-candidate programs within Global Product Teams to support clinical development.
    • Collaborate with discovery biology, computational biology, pharmacology, drug pharmacokinetics, and drug safety teams to design experiments and interpret data for advancing pipeline projects.
    • Work closely with translational oncology to integrate preclinical and clinical datasets and support reverse translation efforts.
    • Contribute to regulatory strategies and author key submission documents (IND, IB, etc.) to support candidate development.
    • Stay updated with new literature to progress preclinical research and understanding of mechanisms of action.
    • Present findings at research meetings and share insights across broader research forums.
    • Foster a culture of scientific excellence, learning, and continuous improvement within the team.

    Qualifications:

    Basic Qualifications:

    • PhD or MD/PhD in Molecular or Cellular Biology, Genetics, Pharmacology, or a comparable biological science with 7+ years of postdoctoral experience in a pharmaceutical/biotech or academic environment. Industry experience is preferred.
    • Expertise in cell signaling and/or cell cycle biology as demonstrated by peer-reviewed publications.
    • Proven track record in oncology translational research and/or drug discovery in the fields of cell cycle/cell signaling pathways.
    • Ability to lead multiple biology research activities and collaborate effectively across teams.
    • Demonstrated leadership skills, including influencing peers and mentoring colleagues to achieve impactful outcomes.

    Preferred Qualifications:

    • Experience in leading preclinical translational oncology research and working with cross-functional clinical development teams.
    • Knowledge of cancer biology areas such as oncogenic signaling, DNA repair, cancer epigenetics, and ADC biology.
    • Experience supporting regulatory submissions and authoring IND study reports.
    • Managerial experience in an industry setting.

    Relocation support available.

    Work Location Assignment: On Premise

    Compensation:

    The annual base salary for this position ranges from $117,300.00 to $195,500.00, with eligibility for Pfizer’s Global Performance Plan, including a 17.5% bonus target and participation in share-based long-term incentive programs. Comprehensive benefits include a 401(k) plan, paid leave, health benefits, and more. Learn more about Pfizer’s benefits here.

    EEO & Employment Eligibility:

    Pfizer is an equal opportunity employer committed to nondiscrimination in employment and complies with all applicable laws. This position requires permanent work authorization in the U.S. Pfizer is an E-Verify employer.

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