Principal Scientist (Phd), Biophysics

3-5 years

$99,900.00 to $166,500.00

La Jolla

10 Dec. 26, 2024

Job Description

Job Type: Full Time Education: PhD Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, CPC Certified, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Role Summary: The Principal Scientist in the Biophysics & HTS group at Pfizer’s Oncology Research Unit in La Jolla is responsible for evaluating drug interactions and protein behavior using biophysical methods. This role requires a high degree of independence in providing biophysical insights to project teams and utilizing advanced techniques to characterize small molecule-protein interactions.

Key Responsibilities:

Biophysical Characterization:
- Independently characterize small molecule-protein interactions using biophysical methods such as SPR, HTRF, ITC, thermal stability assays, MST, and native MS.
- Regularly represent the biophysics team in multi-disciplinary project meetings, providing insights into protein-ligand kinetics and thermodynamics.
Collaboration & Scientific Leadership:
- Collaborate with cross-functional teams to integrate biophysical data into early-stage drug discovery.
- Mentor colleagues and train them in biophysical methods.
- Stay updated on emerging biophysical technologies and integrate them to enhance the group’s capabilities.
Technical Expertise:
- Apply knowledge in enzymology, drug mechanisms, and structural biology to support the discovery of new drug candidates.
- Handle recombinant proteins and apply them in biochemical and biophysical assays.
Research & Innovation:
- Contribute to scientific research and drive innovation in biophysical characterization of drug interactions.
- Publish research findings and share insights with the scientific community.

Basic Qualifications:

PhD in Biophysics, Biochemistry, Structural Biology, or related fields.
3-5 years of experience in drug discovery in pharmaceutical or academic settings.
Expertise in biophysical methods such as SPR, HTRF, ITC, MST, Native MS, and thermal stability assays (e.g., DSF).
Experience in high-throughput screening and plate-based pharmacology.
Strong background in enzymology, drug action mechanisms, and structural biology.
Excellent oral and written communication skills and a team player with a strong publication record.

Preferred Qualifications:

Experience with small-molecule screening using biophysical methods.
Experience in targeting difficult-to-drug targets, protein degradation, and antibody-drug conjugates (ADCs).

Physical/Mental Requirements:

Ability to lift and transport large stacks of plates, plate stackers, and 5L bottles of liquids.
Occasional use of step stools and tools for equipment repair.
Ability to work in a lab environment with safety equipment (lab coat, eye protection, gloves).
Standing and walking for most of the workday.

Work Location & Travel:

Location: On-premise in La Jolla.
Travel: No significant travel required.

Compensation & Benefits:

Salary Range: $99,900 to $166,500 annually, with a 15% bonus target.
Benefits: Comprehensive benefits package, including 401(k) plan, health insurance (medical, dental, vision), paid time off, caregiver leave, and more.
Relocation Assistance: Available based on business needs and eligibility.

EEO & Employment Eligibility:

Pfizer is an equal opportunity employer and adheres to all applicable laws regarding employment and work authorization.

This position offers the opportunity to lead cutting-edge research in drug discovery, with a focus on biophysical characterization and small molecule-protein interactions, while collaborating with experts across multiple disciplines.

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Principal Scientist (Phd), Biophysics

Job Description

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