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Head, Discovery Biologics

8-10 years
Not Disclosed
10 July 22, 2024
Job Description
Job Type: Full Time Education: B.Sc./ M.Sc./ M.Pharm/ B.Pharm/ Life Sciences Skills: Causality Assessment, Clinical SAS Programming, Communication Skills, GCP guidelines, ICD-10 CM Codes, CPT-Codes, HCPCS Codes, ICD-10 CM, CPT, HCPCS Coding, ICH guidelines, ICSR Case Processing, Interpersonal Skill, Labelling Assessment, MedDRA Coding, Medical Billing, Medical Coding, Medical Terminology, Narrative Writing, Research & Development, Technical Skill, Triage of ICSRs, WHO DD Coding

Job Title: Head of Biologics Discovery

About Us:

Fable Therapeutics is a pioneering biotechnology company at the forefront of developing biologics that address therapeutic index limitations and target therapeutic responses precisely. Leveraging advanced structure and sequence-based protein language models, Fable integrates cutting-edge biology and computational methods to tackle complex medical challenges. Backed by a $40M Series A funding round co-led by Versant Ventures and DCVC, we are poised to transform the landscape of protein-based therapeutics through our innovative pipeline and growing pharma research collaborations.

Job Description:

As the Head of Biologics Discovery, you will lead and build a high-performing, diverse team of bench scientists dedicated to advancing our biologics discovery efforts. Your role will involve managing hit discovery and optimization, including the development of hit generation and screening platforms, as well as biochemical and biophysical assays. You will ensure the delivery of high-quality data to progress early hits to development candidates.

You will work closely with the Head of Disease Biology and Pharmacology on target validation and program advancement. Your responsibilities will extend to collaborating with nonclinical development and CMC teams to advance drug candidates towards IND, including early-scale activities. Additionally, you will contribute to Fable’s data strategy for machine learning by delivering high-throughput assay and developability data.

As a member of the DDxR leadership team, you will influence strategic decisions regarding lab infrastructure, informatics, and automation. Your leadership will help shape our therapeutic pipeline and foster a high-performance culture within the team.

Responsibilities:

  • Recruit, manage, and develop a team of biologics discovery scientists to support multiple internal and partnered therapeutic programs.
  • Develop and implement hit discovery and optimization strategies, tailored to pipeline stages and compatible with machine learning approaches.
  • Deliver drug candidates with the necessary potency, specificity, and biochemical activity through high-throughput screening and lab-scale assays.
  • Collaborate with the Head of Biology & Pharmacology on target validation and lead optimization.
  • Lead Discovery Project Teams and manage managerial duties.
  • Partner with CMC to accelerate lead and development candidates towards IND.
  • Oversee outsourcing activities to enhance internal capabilities with support from the DDxR Operations Manager.
  • Contribute to DDxR strategy, including the development of automated lab infrastructure and therapeutic approaches.
  • Promote a high-performance culture of achievement in drug discovery as part of the DDxR leadership team.

About You:

  • PhD/postdoc with 8+ years of industry drug discovery experience, or MSc with 10+ years of experience.
  • Proven track record in biologics discovery and lead optimization.
  • Expertise in biochemical screening assays at various throughputs.
  • Innovative thinker with the ability to apply creative solutions and machine learning in drug discovery.
  • Experienced in people management with a focus on talent development and growth.
  • Clear communicator with excellent presentation skills.
  • Results-oriented with a data-driven approach and commitment to flawless execution.
  • Demonstrated mentoring and leadership capabilities.
  • Collaborative and inclusive mindset.

Our Commitment:

Fable Therapeutics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Accommodations:

If you require accommodations during the interview process, please email hr@oracletherapeutics.com.

Apply now to join us in shaping the future of protein-based therapeutics!